This section contains Canary funded research publications.
Ovarian Cancer
Houshdaran, S., et al. DNA methylation profiles of ovarian epithelial carcinoma tumors and cell lines. PloS One (2010)
Shaw, P.A., et al. Candidate serous cancer precursors in fallopian tube epithelium of BRCA1/2 mutation carriers. Mod Pathol. (2009)
Brown, P.O., et al. The Preclinical Natural History of Serous Ovarian Cancer: Defining the Target for Early Detection. PloS Med. (2009)
Köbel, M., et al.Ovarian carcinoma subtypes are different diseases: implications for biomarker studies. PLoS Medicine (2008)
Lutz, A.M., et al. Cancer screening: A mathematical model relating secreted blood biomarker levels to tumor sizes. PLoS Medicine (2008)
Martin, D.B., et al. MRMer: An interactive open-source and cross-platform system for data extraction and visualization of multiple reaction monitoring experiments. Mol. Cell. Proteomics (2008)
Palmer, C., et al. Systematic Evaluation of Candidate Blood Markers for Detecting Ovarian Cancer. PLoS One (2008)
Faca, V.M., et al.Proteomic analysis of ovarian cancer cells reveals dynamic processes of protein secretion and shedding of extra-cellular domains. PLoS One (2008)
Estep, A., et al. Mutation analysis of BRAF, MEK1 and MEK2 in 15 ovarian cancer cell lines: Implications for therapy. PLoS One (2007)
Scholler, N., et al. Development of a CA125-mesothelin cell adhesion assay as a screening tool for biologics discovery. Cancer Lett. (2007)
Thorpe, J.T., et al. Effects of blood collection conditions on ovarian cancer serum markers. PLoS One (2007)
Bergan, L., et al. Development and in vitro validation of anti-mesothelin biobodies that prevent CA125/Mesothelin-dependent cell attachment. Cancer Lett. (2007)
Scholler, N., et al. Method for generation of in vivo biotinylated recombinant antibodies by yeast mating. J. Immunol. Methods. (2006)
Scholler, N., et al. Bead-based ELISA for validation of ovarian cancer early detection markers. Clin. Cancer Res. (2006)
Lung Cancer
Gazdar, A.F., et al. Lung cancer cell lines: Useless artifacts or invaluable tools for medical science?. Lung Cancer. (2010)
Chari, R., et al. Integrating the multiple dimensions of genomic and epigenomic landscapes of cancer. Cancer Metastasis Rev. (2010)
Qui, J., et al. Occurrence of autoantibodies to Annexin I, 14-3-3 Theta and LAMR1 in prediagnostic lung lancer sera. J. Clin. Oncology. (2008)
Bach, P.B. Is our natural-history model of lung cancer wrong? Lancet Oncol. (2008)
Pancreatic Cancer
Chen R, et al. Pilot Study of Blood Biomarker Candidates for Detection of Pancreatic Cancer. Pancreas (2010)
Faca, V., et al. A mouse to human search for plasma proteome changes associated with pancreatic tumor development. PloS Med. (2008)
Chen R., et al. Comparison of pancreas juice proteins from cancer versus pancreatitis using quantitative proteomic analysis. Pancreas (2007)
Chen R., et al. Quantitative proteomics analysis reveals that proteins differentially expressed in chronic pancreatitis are also frequently involved in pancreatic cancer Mol. Cell. Proteomics (2007)
Pogue-Geile, K.L., et al. Palladin mutation causes familial pancreatic cancer and suggests a new cancer mechanism. PloS Med. (2006)
Chen R., et al. Quantitative proteomic profiling of pancreatic cancer juice. Proteomics (2006)
Prostate Cancer
Newcomb, L.F., et al. Canary Prostate Active Surveillance Study: Design of a multi-institutional active surveillance cohort and biorepository. Urology (2009)
Imaging
Deshpande N., et al. Molecular ultrasound imaging: current status and future directions. Clinical Radiology (2010)
Pysz MA, et al. Molecular imaging: current status and emerging strategies. Clinical Radiology (2010)
Deshpande N., et al. Molecular ultrasound assessment of tumor angiogenesis. Angiogenesis (2010)
Pysz MA, et al. Antiangiogenic Cancer Therapy: Monitoring with Molecular US and a Clinically Translatable Contrast Agent (BR55). Radiology (2010)
Willmann JK, et al. Targeted Contrast-Enhanced Ultrasound Imaging of Tumor Angiogenesis with Contrast Microbubbles Conjugated to Integrin-Binding Knottin Peptides. Journal of Nuclear Medicine (2010)
Willmann, J.K., et al. Targeted microbubbles for imaging tumor angiogenesis: assessment of whole-body biodistribution with dynamic micro-PET in mice. Radiology (2008)
Willmann, J.K., et al. Dual-targeted contrast agent for US assessment of tumor angiogenesis in vivo. Radiology (2008)
Willmann, J.K., et al. US imaging of tumor angiogenesis with microbubbles targeted to vascular endothelial growth factor receptor type 2 in mice. Radiology (2008)
Lutz, A.M., et al. 2-deoxy-2-[F-18]fluoro-D-glucose accumulation in ovarian carcinoma cell lines. Mol. Imaging Biol. (2007)
Blood Biomarkers
Pan S., et al. Mass Spectrometry Based Targeted Protein Quantification: Methods and Applications. Journal of Proteome Research (2008)
Borugian, M.J., et al. The Canadian Partnership for Tomorrow Project: building a pan-Canadian research platform for disease prevention. CMAJ (2010)
May, D., et al. A software platform for rapidly creating computational tools for mass spectrometry-based proteomics. J Proteome. Res. (2009)
Lutz, A.M., et al. Cancer screening: A mathematical model relating secreted blood biomarker levels to tumor sizes. PLoS Medicine (2008)
Scholler, N., et al. Use of cancer-specific yeast-secreted in vivo biotinylated recombinant antibodies for serum biomarker discovery. J. Transl. Med. (2008)
Martin, D.B., et al. MRMer: An interactive open-source and cross-platform system for data extraction and visualization of multiple reaction monitoring experiments. Mol. Cell. Proteomics (2008)
Canary-American Cancer Society Postdoctoral Fellowships
Maher, C.A., et al. Chimeric transcript discovery by paired-end transcriptome sequencing. PNAS. (2009)
Maher, C.A., et al. Transcriptome sequencing to detect gene fusions in cancer. J. of Nature. (2009)
Abbott, K.L., et al. Targeted glycoproteomic identification of biomarkers for human breast carcinoma. J. of Proteome Res. (2008)
Bingham, J.L., et al. Extent and diversity of human alternative splicing established by complementary database annotation and microarray analysis. OMICS (2008)
Varambally, S., et al. Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science (2008)
Hayes, G.M. et al. A novel secretin receptor splice variant potentially useful for early diagnosis of pancreatic carcinoma. Gastroenterology (2007)
Hayes, G.M. et al. Serine-arginine protein kinase 1 overexpression is associated with tumorigenic imbalance in mitogen-activated protein kinase pathways in breast, colonic, and pancreatic carcinomas. Cancer Res. (2007)
Liu, J.T., et al. Dual-axes confocal reflectance microscope for distinguishing colonic neoplasia. Cancer Epidemiol. Biomarkers Prev. (2007)
Liu, J.T., et al. Miniature near-infrared dual-axes confocal microscope utilizing a two-dimensional microelectromechanical systems scanner. Opt. Lett. (2007)
Carrigan, P.E., et al. Distinctive heavy metal composition of pancreatic juice in patients with pancreatic carcinoma. J Biomed Opt. (2006)
Technology Seed Grants
Anderson, N.L., et al. SISCAPA peptide enrichment on magnetic beads using an inline beadtrap device. Mol Cell Proteomics (2009)
Pope, M.E., et al. Anti-peptide antibody screening: Selection of high affinity monoclonal reagents by a refined surface plasmon resonance technique. J Immunol Methods. (2009)
Fredriksson, S., et al. Multiplexed proximity ligation assays to profile putative plasma biomarkers relevant to pancreatic and ovarian cancer. Clin. Chem. (2008)
Burbulis, I., et al. Quantifying small numbers of antibodies with a 'near-universal' protein-DNA chimera. Nat. Methods. (2007)
Berlin, A. SnooperScope Biopsy Probe: Actuation Feasibility Study (2007)
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