Stopping Cancer Early – The Best Possible Investment



    Early Detection of Cancer Annual Conference- EDx22 – hosted by OHSU Knight Cancer Institute, The Canary Center at Stanford, and Cancer Research UK brought together great minds to collaborate in cancer early detection research!

    November 17, 2022

    This year’s sold-out conference had engaging discussions, talks from submitted abstracts, and opportunities to collaborate with experts from across the globe. There was also the opportunity to debate provocative early detection challenges.

    This year’s interesting Agenda and Speakers:

    Keynote: Population and tumor heterogeneity in cancer genome science
    Speaker: John Carpten, USC

    From models to mechanisms to humans
    Topic chairs: Simon Leedham & Victor Velculescu
    Speakers: Jos Jonkers, Ryan Schenck, Sabine Tejpar, Victor Velculescu

     Yeuk Pin Gladys Poon – The clonal evolution preceding leukemia development revealed using single-cell DNA sequencing

     Shiqin Liu – Shed Trop2 Extracellular Domain is a Potential Liquid Biomarker for High-risk Prostate Cancer and a Regulator of Prostate Cancer Progression

    Panel: How should we evaluate Multi Cancer Early Detection Tests?
    Moderator: Michelle Le Beau
    Speakers: Allan Hackshaw, Minetta Liu, Anne Mackie, Josh Ofman

    Emerging technologies for early detection and precision diagnosis
    Topic chairs: Rob West & Thuy Ngo
    Speakers: Brian Cunningham, Thuy Ngo, Mirabela Rusu, Rob West

     Jie Wang – Acoustic Fabrication of Living Cardiomyocyte-based Hybrid Biorobots

    Travis Moore – Robust CNV detection using single-cell ATAC-seq

    Great Debate 1: There is no such thing as over-diagnosis. Every diagnosis will help us better understand the biology of the cancer, eventually advancing early cancer detection and management.
    Speakers: Nora Pashayan & Eithne Costello


    Day 2, Opening remarks – Tanya Stoyanova, Canary Center at Stanford University

    Keynote Panel: A funding agency perspective on early detection
    Speakers: Karen Knudsen, Phil Castle, Catherine Elliott

    Microbiological risk factors for early detection
    Topic chairs: Xin Lu & Zhenzhen Zhang
    Speakers: Emma Allen-Vercoe, Curtis Huttenhower, Gabe Kwong and Zhenzhen Zhang

    Danielle Brasino – A New, Organ-on-Chip Platform to Study the Relationship Between Gut Microbiota and Distal Tumors

    Michael Fadel – Diagnostic performance of a non-invasive breath test for colorectal cancer: COlorectal BReath Analysis 1 (COBRA1) study

    Panel: What can we learn from trials that return unexpected results on mortality benefit from early detection biomarkers/tests?
    Moderator: Peter Johnson
    Speakers: Christine Berg, Usha Menon

    Great Debate 2: Single-organ cancer screening is failing public health – Multi-cancer early detection tests are the only way forward
    Speakers: Paul Limburg & Bob Steele

    Day 3, Opening remarks – George Hanna, Imperial College London

    Joshua Bull – Mathematical Tools for Spatial Analysis of Multiplex Medical Images

    Elinor Nemlander – Predicting lung cancer in never smokers, former smokers and current smokers using machine learning – results from a computer-based detailed symptom questionnaire given to patients investigated at a specialist lung clinic

    What is needed for an earlier cancer detection test to have clinical impact?
    Topic chairs: Tom Beer & Rebecca Fitzgerald
    Speakers: Hormuzd Katki, Larry Kessler, Chris Peters, Sharmila Anandasabapathy

    Conference closing remarks – George Hanna