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Archive for the ‘Cancer Early Detection’ Category
Canary’s new: High Grade Serous Ovarian Cancer Initiative. HGSOC is the most common and lethal form of ovarian cancer.
February 4, 2020
Ovarian cancer remains the most lethal gynecologic malignancy in the United States. In 2018, over 22,000 new cases were diagnosed and 14,000 women lost their lives to the disease.
Ovarian cancer is made up of distinct subtypes. High grade serous ovarian carcinoma is 70% of cases, and is the most lethal subtype accounting for over 60% of ovarian cancer deaths.
People who have inherited mutations in BRCA genes are at higher risk for certain types of cancer, including HGSOC. In looking very carefully at the fallopian tubes removed from BRCA mutation carriers, the discovery was made that the fallopian tube was a site of origin for HGSOC – not the ovary itself, but the fallopian tube. This understanding over the past 15 years represents a paradigm shift in the origin of the HGSOC and opportunity for us to better understand how the cancer develops and design better strategies for early detection and prevention.
80% of HGSOC are diagnosed at a late stage!
We want to eliminate deaths from HGSOC by early detection and prevention.
There are currently no effective methods for early detection for ovarian cancer. Substantial progress has been made in identifying the putative precursor lesions for ovarian cancers.
Our focus is to define the role of the fallopian tube microenvironment in the development of high grade serous ovarian cancer, with the ultimate objective to find targets for prevention and markers of early disease onset for early detection. We are tackling the problem from multiple directions to ensure the greatest probability of success.
It is unclear which precursor lesions are likely to progress and/or be associated with invasive disease. A critical knowledge gap is how the various constituents of the fallopian tube microenvironment impact tumor development or progression.
Achieving our goals requires a multi-institutional, multi-disciplinary effort. The team we assembled is made up of gynecologic oncologists, molecular biologists, epidemiologists, pathologists and bioinformaticians. The team is world class and has the requisite expertise to capitalize on complementary molecular profiling. Our research plan leverages powerful, broad-based discovery approaches to tackle this difficult challenge of early detection.
Dr. Heidi Aumen explains more:
Canary’s Prostate Active Surveillance Study (PASS) receives $6.7M NCI grant to support growth of the multi-center study!
December 2, 2019
PASS was established in 2008 with funding from the Canary Foundation, demonstrating how we invest in promising early research!
“PASS was launched with six participating centers in 2008,” said PASS Deputy Director Dr. Lisa Newcomb, a Hutch cancer prevention researcher. “With this grant, we’ll be up to 11 sites. Fred Hutch is the centralized repository — specimens are sent to the Hutch from all the sites — and we have procedures for sharing the data and the specimens among the group [members] and with other researchers.”
The grant is designed to support the infrastructure of the PASS cohort, including the collection of follow-up data, management of the database and management of the biospecimen repository.
PASS participants are all early-stage prostate cancer patients who chose active surveillance, not immediate surgery or radiation, to manage their cancer. In active surveillance, patients receive regular PSA (prostate-specific antigen) testing, biopsies and digital-rectal exams to monitor whether the cancer grows or becomes more aggressive.
According to research, more than 30% of men have slow-growing prostate cancer and won’t necessarily benefit from radical treatments that can cause debilitating side effects such as urinary incontinence and impotence. Data from patients with early-stage prostate cancers who choose active surveillance can provide key insights into who’s most at risk from their cancers, and when.
Using the cohort for risk-prediction modeling, Newcomb said, could help “determine who either harbors or will progress to a bad cancer, which cancers are aggressive and which really aren’t.”
“We want to help identify the men who can go home and not worry about their cancer. We’re looking at both ends of the spectrum — making active surveillance less active and identifying the people who will benefit from treatment early.” – Dr. Lisa Newcomb
“We are thrilled,” said Newcomb regarding the transition from Canary Foundation support to NCI funding.
Fred Hutch has had a longstanding relationship with the Canary Foundation and has been the recipient of many grants from the foundation powering work in early detection. The fifth floor of Fred Hutch’s Arnold Building, home to its Public Health Sciences Division, is named for the foundation.
At present, participating sites for PASS include the University of California, San Francisco; Stanford University; Emory University; Beth Israel Deaconess Medical Center/Harvard Medical School; University of Michigan; University of Texas Health Science Center, San Antonio; Eastern Virginia Medical School; Veterans Affairs Puget Sound Health Care System; University of Washington and University of British Columbia.
Interested in PASS? Contact Dr. Lisa Newcomb or go to https://canarypass.org/
Interested in accessing Canary PASS Active Surveillance Risk Calculators? The PASS Risk Calculators provide estimates of how likely a man is to have more aggressive cancer in the future. These tools are intended to be useful for clinicians and their patients as they determine optimal methods of active surveillance. Access the risk calculators: https://canarypass.org/pass-risk-calculator/
To read the full article by Diane Mapes, a staff writer at Fred Hutchinson Cancer Research Center, please go to: https://www.fredhutch.org/en/news/center-news/2019/11/prostate-cancer-study-nci-funding-grant.html
The Early Detection of Cancer Conference at Stanford!
October 9, 2019
Canary Center at Stanford, Cancer Research UK, and the OHSU Knight Cancer Institute, hosted the Early Detection of Cancer Conference September 24 – 26 at the Frances C. Arrillaga Alumni Center, Stanford, California. Approximately 370 attendees, from 120 institutions, and 11 countries outside of the USA (including Australia, Canada, China, Finland, France, Great Britain, India, Netherlands, South Korea, Switzerland, and Ukraine) brought forth their latest findings and ideas. The annual Conference brings together experts in early detection from multiple disciplines to share ground breaking research and progress in the field.
The conference is part of a long-term commitment to invest in early detection research, to understand the biology behind early stage cancers, find new detection and screening methods, and enhance uptake and accuracy of screening.
The talks ventured widely, from finding ways to extract more information from cell-free DNA in blood, to building cohorts of people at high risk of cancer to prospectively study the emergence of disease, to the role of the tumor micro-environment and the immune system in cancer early detection, and going beyond traditional risk factors to better select populations for targeted cancer screening.
Highlights of this year’s conference included: More »
Project Baseline aims to map human health
February 3, 2019
What if we could view changes in the body earlier than early to warn of possible disease? That is the aim of Project Baseline, to map human health. The New York Times published “Project Baseline Aims to Ward Off Illness Before We Get Sick” by Anahad O’Connor (Oct 2018). The study is recruiting 10,000 adults. And each will be examined and followed for at least four years. So the goal is to discover the earliest warning signs of cancer, heart disease and other killers. Participants, the first of whom was enrolled in 2017, are called Baseline Explorers.
Project Baseline is the result of conversations in 2013, led by Google X’s Andrew Conrad. He consulted with Dr. Sam Gambhir, MD, chair of Radiology at Stanford University and director of the Canary Center for Cancer Early Detection. And also with Robert M. Califf, MD, professor of Cardiology in the School of Medicine, Duke University.
Conrad (now CEO of Verily, a spin out of Google X) was interested in exploring with these two notable healthcare thought leaders, one in cancer and the other in cardiology, about how to create what has become a landmark study. Both had deep experience in working with large patient cohorts and focus on early detection of disease. The project has formed teams across the country.
Seeking to create a baseline of health
Traditional trials focus on those who have a disease. So Project Baseline, as the name implies, mainly enrolls healthy individuals gathering enormous amounts of information. Baseline equips enrollees with wearable technology from Verily that tracks sleep patterns, heart rhythms and physical activity. The team is developing tools and technologies to collect, organize, analyze and curate the data.
And investigators are determining the best ways to share data with participants that is helpful to them. They are looking at how they can engage with their medical professionals.
Canary Foundation and the Canary Center at Stanford for Cancer Early Detection
Dr. Gambhir has served as Canary Foundation’s scientific director for more than a decade. He led the development of the Canary Center at Stanford for Cancer Early Detection. The Canary Center is a partnership forged in 2008 between Stanford University and Canary Foundation under the leadership of Don Listwin, based on the foundation’s mission. And interesting to know, Canary Center is the first program Stanford has focused entirely on cancer early detection.
American Cancer Society Report January 2019 is hopeful. Yet it motivates us to work harder at finding better tests
January 16, 2019
The new American Cancer Society report shows us that cancer deaths have dropped by 27% since their peak in 1991. The decrease is attributed to early detection, better treatments and a reduction in smoking rates. The ACS report also points to a socio-economic disparity in the numbers, based on broad county and area reports collected by Surveillance, Epidemiology, and End Results (SEER – a National Cancer Institute source of epidemiologic information on the incidence and survival rates of cancer in the United States, where access to education and healthcare remains a problem. Additionally, lower incidence has been slower in cancers such as lung and prostate. Also, rates of new cases rose for pancreatic and other cancers. While the overall decline in rates is great news, we must keep up the momentum to create early detection tests to save lives as cancer remains the second cause of death in the United States (22% in 2016), and a major health issue worldwide.
The report states that in 2019, 1,762,450 new cancer cases and 606,880 cancer deaths are projected to occur in the United States. From the report: “…the Lifetime probability of being diagnosed with invasive cancer is 39.3 % for men and 37.7% for women. Prostate, lung and colorectal cancers (CRCs) account for 42% of all cases in men, with prostate cancer alone accounting for nearly 1 in 5 new diagnoses. For women, the 3 most common cancers are breast, lung, and colorectum, which collectively represent one-half of all new diagnoses; breast cancer alone accounts for 30% of all new cancer diagnoses in women. The reasons for the excess overall risk in men are not fully understood, but partly reflect differences in environmental exposures, endogenous hormones, and probably complex interactions between these influences.”
Canary Foundation has been on the forefront of stimulating the field of cancer early detection globally by demonstrating cancer early detection tests as well as hosting scientific symposiums, mentoring researchers choosing the early detection path, and forging important national and international partnerships. To address access problems, Canary’s investments have focused, when possible, on cost-effective tests as a path to bridging the socio-economic disparities. Examples can be found in are our funded studies in enhance ultrasound using microbubbles, where ultrasound is found in doctor’s offices worldwide, representing an imaging modality in development useful for multiple cancers that is low-cost, non- invasive and with the additional benefit of not using radiation.
Canary remembers innovator and imaging expert Juergen Willmann
February 15, 2018
Juergen Willmann, MD, a professor of radiology at Stanford and a member of the Canary Foundation pancreatic team, died Jan. 8 in a car accident in Palo Alto.
Willmann was known for developing an imaging tool called targeted contrast microbubbles that, in combination with ultrasound, could be used to detect early tumors and target the delivery of drugs. Over the course of a decade, his lab at Stanford advanced the microbubble work from testing in animals all the way to the first clinical imaging trials in humans.
Here, some of Willmann’s closest colleagues share their feelings about his work, passion and the impact he had on the field of cancer early detection.
“I have been working closely with Juergen for more than a decade on the early detection of pancreatic cancer. We first met at a Canary Foundation conference at Stanford, where I had been asked to lead the Pancreas Cancer Early Detection Team. Juergen was just starting his career in radiology and had a strong background in engineering and cancer science. I had been working on biomarkers of pancreatic cancer using proteomic technology. We realized we could create an early detection test using microbubble technology and endoscopic ultrasound or abdominal ultrasound, if we could create a microbubble target that would be unique to pancreatic cancer and pre-cancer vasculature. … My lab spent the next 5 years finding and validating the target. … Together, with Juergen’s lab we were able to document the target was present in human tissue and then Juergen was able to demonstrate the feasibility of using microbubbles to detect very small pancreatic cancers in mouse models. After this decade of work, our next efforts were to move this into the clinical realm, with Juergen taking the lead on this part of the endeavor. Juergen was passionate about pancreatic cancer and early detection. He was a brilliant scientist, dedicated, and innovative. He will be deeply missed not only by his colleagues, but by the pancreatic cancer community as a whole. Ultimately, I hope that his collaborative work will remain a foundation for continued research in earlier detection of pancreatic cancer.”
Teri Brentnall, M.D.
Professor of Medicine, University of Washington
Pancreatic Team Leader, Canary Foundation
“Juergen was committed to helping advance the field of early cancer diagnostics. His work on using ultrasound imaging with targeted microbubbles will continue to have an impact for many years to come. His passion and optimism will be sorely missed. I will miss him dearly but know his contributions to biomedical science will live on.”
Sanjiv Sam Gambhir, M.D., Ph.D.
Chair, Department of Radiology
Director, Canary Center at Stanford for Cancer Early Detection
Stanford University School of Medicine
Andrew A. Berlin, Ph.D.
Distinguished Member of the Technical Staff
Draper
“Juergen was committed to helping advance the field of early cancer diagnostics. His work on using ultrasound imaging with targeted microbubbles will continue to have an impact for many years to come. His passion and optimism will be sorely missed. I will miss him dearly but know his contributions to biomedical science will live on.”
“A year ago I received an unexpected phone call from Dr. Juergen Willmann asking me to work with his team at the Canary Center at Stanford to make medical ultrasound more sensitive for early detection of cancer. Working closely with Juergen to adapt technologies Draper had originally developed for finding tiny hidden features in satellite images to instead seek out microscopic bubbles within cancer tumors turned out to be one of the best experiences I have ever had. His vision for enabling early cancer detection without using radiation, and his passion for collaborating with engineers like myself to pull it off, provided a sense of excitement and joy that inspired, and will continue to inspire, many of us to follow his lead until these technologies are used to help patients every day.”Canary funds four collaborative studies that pair faculty at Stanford with faculty at the University of Cambridge
Cancer early detection researchers develop future collaborations on a punting excursion in Cambridge, UK in September 2017.
Canary Foundation was ahead of the cancer early detection wave when it started in 2004. Since then, academic institutions, such as the University of Cambridge in the UK and the University of Calgary in Canada, have looked to Canary for advice as they build out their own cancer early detection programs.
This year, one such collaboration is taking shape in dynamic ways. Canary’s partnership with the University of Cambridge has resulted in four promising studies that partner researchers from Cambridge with researchers from Stanford. These projects, jointly funded by Canary Foundation and the Cancer Research UK Cambridge Centre, will explore innovative ways to detect prostate, lung, esophageal and renal cancers at an early stage.
In order to receive seed grants for these projects, applications had to include faculty at both Stanford and Cambridge. By fostering this transatlantic collaboration, Canary hopes to bring outstanding academic and clinical researchers from the US and UK together to tackle some of the most challenging questions in detecting cancer sooner.
The awards were announced at Cambridge’s third annual early detection symposium on January 15. You can read more about these collaborations below or by watching the video.
“A multi-modal approach to discover novel blood-based biomarkers for early detection of poor prognosis prostate cancer”
Tanya Stoyanova, an assistant professor of radiology at the Canary Center, is partnering with Vincent Gnanpragasam, an urologist at Cambridge University Hospitals, to identify different types of tumors in men with prostate cancer. The goal is to distinguish between aggressive tumors that would require immediate treatment, and slow-growing tumors that may not need treatment immediately but could be monitored closely so that any changes in the tumor can be picked up and acted upon. Their project will use data from a number of sources including tumor DNA found circulating in the blood, protein molecules found in cancer cells, and MRI imaging of the tumor.
“Early cancer detection through transcriptomic analysis of host immune cells”
Tom Soh, a professor of radiology at the Canary Center, is exploring new ways to detect early-stage lung cancer through his partnership with Robert Rintoul, a thoracic consultant at Cambridge University Hospitals. The pair is studying the immune cells in blood samples to see if there are particular signals that could be used to identify lung cancer early.
“Levitating a sponge for the early detection of Esophageal Adenocarcinoma”
Utkan Demirci, a professor of radiology at the Canary Center, is working with Rebecca Fitzgerald, Cambridge’s early detection program co-lead, to detect early signs of esophageal cancer. They will use a new nanotechnology developed by Demirci that separates different types of cells using a magnetic field. The technology will be applied to the mixture of cells collected from patients that are given a Cytosponge test developed by Fitzgerald that can diagnose Barrett’s esophagus – a common condition that, in some cases, develops into esophageal cancer.
“Early detection of renal cell carcinoma using DNA methylation markers in urine”
Olivier Gevaert, an assistant professor of medicine and of biomedical data science at Stanford, and John Leppert, an associate professor of urology at Stanford, are teaming up with Charlie Massie, a group leader in Cambridge’s early detection program. They will study whether it is possible to detect the early stages of a type of kidney cancer (Renal Cell Carcinoma) using biomarkers found in urine. Their research will look at specific signals in the DNA cells called methylation.
Lung Cancer Biomarker Discovered by Canary Researchers Attracts New Interest From Academia and Industry
November 14, 2017
Team lead Dr. Samir Hanash discusses biomarker SFTPB’s journey from discovery to commercialization
Searching for a needle in a haystack. That’s how Dr. Samir Hanash described the long, intensive process of finding a blood-based biomarker to detect lung cancer. So, when the Canary Lung Cancer Team, with Hanash at the helm, discovered a promising candidate called pro surfactant protein b (SFTPB), the potential impact was tremendous, especially since there has been only one other similar discovery to date.
Early validation studies of SFTPB have been so promising that multiple parties – among them The University of Texas MD Anderson Cancer Center and tech startup MagArray – have entered into negotiations with Canary Foundation to do further testing.
As part of a comprehensive lung cancer screening process, SFTPB has the potential to address shortcomings like false positives on CT scans as well as more accurately identify who should be screened and predict how frequently the person should be monitored.
Dr. Hanash recently discussed the discovery of biomarker SFTPB and its potential in a conversation with Canary Foundation that can be read below.
Canary Foundation: Can you explain the current state of lung cancer screening and why it is important to add biomarkers into the process?
Dr. Samir Hanash: The uptake of lung cancer screening with low dose CT has been quite modest in the U.S. and not at all in European countries. Blood-based biomarkers to determine the need for CT would represent a paradigm shift.
CF: When did your search for a lung blood biomarker begin?
SH: It began more than 15 years ago when I was at the University of Michigan.
CF: What makes it so difficult to pinpoint promising lung cancer biomarkers?
SH: Tremendous disease heterogeneity (diversity), limited availability of most informative samples for early detection, the need for in-depth high sensitivity methodology to find the needle in the haystack.
CF: At what point in the process did SFTPB emerge as a potential biomarker candidate?
SH: It emerged when we integrated data from mouse models of lung cancer with human data and lung cancer cell line data.
CF: What qualities does SFTPB have that led you to focus on it?
SH: We have subjected it to a multitude of blinded validation studies, and it came out significant for discriminating between lung cancer and controls.
CF: Validation studies of SFTPB have been very promising. What do these studies reveal in terms of the biomarker’s potential?
SH: That as part of a broader panel of biomarkers for lung cancer, it can be an effective tool for lung cancer screening.
CF: Now other groups are interested in further testing SFTPB and Canary Foundation has developed a licensing agreement to facilitate this. Why is additional testing necessary and what are the potential outcomes?
SH: There are many clinical indications related to lung cancer for which SFTPB may or may not be useful.
CF: If further studies of SFTPB continue to produce promising results, what are the next steps? How long could it be before SFTPB is used in lung cancer screening?
SH: That depends on performance in the most rigorous validation studies that meet FDA requirements.
Samir M. Hanash, M.D., Ph.D., is a professor in the Department of Clinical Cancer Prevention at The University of Texas MD Anderson Cancer Center in Houston. We thank him for his insights.
Early Cancer Detection Initiative joins Canary Foundation Flock
October 24, 2017
University of Calgary cancer researchers to collaborate with top funding group
The Canary Foundation is now backing research at the University of Calgary. From left: Jon Meddings, dean of the Cumming School of Medicine; Elizabeth Cannon, president and vice-chancellor of the University of Calgary; Don Listwin, founder and CEO of the Canary Foundation; Tina Rinker, lead, Early Cancer Detection Initiative; Bill Rosehart, dean of the Schulich School of Engineering. Photo by Pauline Zulueta
When you learn Don Listwin has an engineering degree, it all makes perfect sense.
The man who started the Canary Foundation, the world’s leading non-profit funding agency for early-detection cancer research, is looking to defeat the disease the way an engineer would. His strategy: prevent the problem before it starts, rather than trying to fix it after disaster has struck.
“Early detection of cancer means confronting the disease when it is most treatable and chances for full recovery are greatest,” explains Listwin, founder and chairman of the Canary Foundation, and an electrical engineering graduate. “By focusing our efforts on research dealing with early detection and pre-emptive testing, we are finding and fighting cancer when it is most vulnerable and easiest to defeat.”
This week, the Early Cancer Detection Initiative at the University of Calgary officially joins the esteemed list of research programs backed by the Canary Foundation. Since 2004, the foundation has helped fund a select group of collaborative laboratories, starting with the Fred Hutchinson Cancer Research Center in Seattle. The University of Calgary joins the Canary Center at Stanford; the MD Anderson Cancer Center, Houston, Texas; Cancer Research U.K.; and OHSU Knight Cancer Institute in Portland, Ore. on the short list of Canary Foundation collaborators.
For Listwin, cancer is a very personal adversary. Having lost his mother to misdiagnosed late-stage ovarian cancer and watched his father fight colon cancer, the Canadian technology mogul decided to do something about it.
Having previously climbed to the near-pinnacle of his chosen industry — Listwin was CEO of Openwave Systems and had been the number two executive at Cisco Systems — he took on cancer with the same drive and determination, launching the Canary Foundation.
Listwin says early-detection research like that taking place at UCalgary is key to ensuring victims become survivors. “The work taking place here in Calgary on diagnostic tools that will allow for early detection of high-mortality, treatment-resistant cancers is vital to our goal,” he says. “We are proud and enthused to be supporting the University of Calgary’s Early Cancer Detection Initiative.”
A partnership established by the Arnie Charbonneau Cancer Institute between the Schulich School of Engineering, the Cumming School of Medicine, and the Tom Baker Cancer Centre, the pan-university Early Cancer Detection Initiative’s mission is three-fold. Namely to develop strategies and methods for non-invasive earlier detection of cancer, discover better ways to predict the behaviour of individual cancers, and accelerate the development of new commercially viable cancer detection tests and technologies.
Led by bioengineering professor Kristina Rinker, PhD, the Early Cancer Detection Initiative team, including medical oncologist Dr. Don Morris and surgical oncologist Dr. Oliver Bathe of the Charbonneau Cancer Institute and the Department of Oncology, aims to engage with researchers across campus.
The goal is to advance cancer detection technology development through providing funding opportunities, fostering interdisciplinary collaborations, and building connections to local and international mentors, researchers, and resources. Researchers are currently investigating new ways of detecting those at risk of developing cancer, through blood tests for detecting early disease, body fluid analysis, and technologies to detect metastatic cancer, among other key projects.
Rinker is director of the Centre for Bioengineering Research and Education, and associate professor of Chemical and Petroleum Engineering at the Schulich School of Engineering, associate professor in the Department of Physiology and Pharmacology at the CSM and member of the Charbonneau Cancer Institute. She says the Canary Foundation’s support is a significant boost to the research taking place in Calgary, and it places the university in a position to work and collaborate with the world’s best.
“We are very excited to join the dedicated international team of researchers in the Canary network to detect cancer earlier and open doors to stopping or even reversing cancer progression,” explains Rinker.
The University of Calgary’s multidisciplinary Engineering Solutions for Health: Biomedical Engineering research strategy is focused on developing solutions for pressing health challenges in disease and injury prevention, diagnosis and treatments. Researchers are applying systems engineering principles to continuously improve the health system.
This article by Michael Platt originally appeared on the University of Calgary website (www.ucalgary.ca).
Cycling for Canary – one rider’s drive
June 13, 2016
Nitish Amin is a 3-time Canary Challenge participant and is currently gearing up for his fourth Challenge, riding with team Cisco. In this guest blog he reflects on his love of biking and passion for supporting cancer early detection.
Growing up in India, I biked everywhere, every day, as a child.
I grew up, as we all do, moved to the United States and set biking aside. However, three years ago, I started biking again.
The first time I got on my Cannonade (that’s a really great bike, if you don’t know) something just felt right. I have that feeling when I get on the saddle every Sunday morning.
I see more when I’m on my bike than when I’m in a car. I usually take the roads and routes that I haven’t explored. It is an amazing hobby that allows me to slow down, even when I’m going 20+ miles per hour. I stop to talk to people. For the next few hours that I’m on my bike, it’s just me, nature, and my fellow biking enthusiasts. I am always amazed at how new many friends I make see when I’m riding. These friends I made, we call ourselves, “CRANK OF DAWN” because we like to ride early.
It’s the same during my 8+ years at Cisco, where I get to see how many great people I work with. I am a Software Technology Manager and while we’re all moving fast to innovate and to change the world, when we take a moment to slow down, enjoy what we do, we get to see a little more, take a few unexplored paths, and just talk to each other. We also have time to give back together.
I learned about the Canary Foundation through Cisco’s volunteer program. It is the non-profit organization dedicated solely to the funding, discovery and development of tests for early cancer detection. This photo of me is during a 50-mile ride for the Canary Challenge. I like that Cisco encourages us to give back in ways that are personal to us, and in our local communities.
My father started one of the first early cancer detection centers back in the 1970s in Gujarat, India. When I ride for Canary, I feel that sense of connection between where I am now, at Cisco, and where I came from, all while contributing to a worthy cause.
