Archive for 2017
Lung Cancer Biomarker Discovered by Canary Researchers Attracts New Interest From Academia and Industry
November 14, 2017
Team lead Dr. Samir Hanash discusses biomarker SFTPB’s journey from discovery to commercialization
Searching for a needle in a haystack. That’s how Dr. Samir Hanash described the long, intensive process of finding a blood-based biomarker to detect lung cancer. So, when the Canary Lung Cancer Team, with Hanash at the helm, discovered a promising candidate called pro surfactant protein b (SFTPB), the potential impact was tremendous, especially since there has been only one other similar discovery to date.
Early validation studies of SFTPB have been so promising that multiple parties – among them The University of Texas MD Anderson Cancer Center and tech startup MagArray – have entered into negotiations with Canary Foundation to do further testing.
As part of a comprehensive lung cancer screening process, SFTPB has the potential to address shortcomings like false positives on CT scans as well as more accurately identify who should be screened and predict how frequently the person should be monitored.
Dr. Hanash recently discussed the discovery of biomarker SFTPB and its potential in a conversation with Canary Foundation that can be read below.
Canary Foundation: Can you explain the current state of lung cancer screening and why it is important to add biomarkers into the process?
Dr. Samir Hanash: The uptake of lung cancer screening with low dose CT has been quite modest in the U.S. and not at all in European countries. Blood-based biomarkers to determine the need for CT would represent a paradigm shift.
CF: When did your search for a lung blood biomarker begin?
SH: It began more than 15 years ago when I was at the University of Michigan.
CF: What makes it so difficult to pinpoint promising lung cancer biomarkers?
SH: Tremendous disease heterogeneity (diversity), limited availability of most informative samples for early detection, the need for in-depth high sensitivity methodology to find the needle in the haystack.
CF: At what point in the process did SFTPB emerge as a potential biomarker candidate?
SH: It emerged when we integrated data from mouse models of lung cancer with human data and lung cancer cell line data.
CF: What qualities does SFTPB have that led you to focus on it?
SH: We have subjected it to a multitude of blinded validation studies, and it came out significant for discriminating between lung cancer and controls.
CF: Validation studies of SFTPB have been very promising. What do these studies reveal in terms of the biomarker’s potential?
SH: That as part of a broader panel of biomarkers for lung cancer, it can be an effective tool for lung cancer screening.
CF: Now other groups are interested in further testing SFTPB and Canary Foundation has developed a licensing agreement to facilitate this. Why is additional testing necessary and what are the potential outcomes?
SH: There are many clinical indications related to lung cancer for which SFTPB may or may not be useful.
CF: If further studies of SFTPB continue to produce promising results, what are the next steps? How long could it be before SFTPB is used in lung cancer screening?
SH: That depends on performance in the most rigorous validation studies that meet FDA requirements.
Samir M. Hanash, M.D., Ph.D., is a professor in the Department of Clinical Cancer Prevention at The University of Texas MD Anderson Cancer Center in Houston. We thank him for his insights.
October 24, 2017
University of Calgary cancer researchers to collaborate with top funding group
When you learn Don Listwin has an engineering degree, it all makes perfect sense.
The man who started the Canary Foundation, the world’s leading non-profit funding agency for early-detection cancer research, is looking to defeat the disease the way an engineer would. His strategy: prevent the problem before it starts, rather than trying to fix it after disaster has struck.
“Early detection of cancer means confronting the disease when it is most treatable and chances for full recovery are greatest,” explains Listwin, founder and chairman of the Canary Foundation, and an electrical engineering graduate. “By focusing our efforts on research dealing with early detection and pre-emptive testing, we are finding and fighting cancer when it is most vulnerable and easiest to defeat.”
This week, the Early Cancer Detection Initiative at the University of Calgary officially joins the esteemed list of research programs backed by the Canary Foundation. Since 2004, the foundation has helped fund a select group of collaborative laboratories, starting with the Fred Hutchinson Cancer Research Center in Seattle. The University of Calgary joins the Canary Center at Stanford; the MD Anderson Cancer Center, Houston, Texas; Cancer Research U.K.; and OHSU Knight Cancer Institute in Portland, Ore. on the short list of Canary Foundation collaborators.
For Listwin, cancer is a very personal adversary. Having lost his mother to misdiagnosed late-stage ovarian cancer and watched his father fight colon cancer, the Canadian technology mogul decided to do something about it.
Having previously climbed to the near-pinnacle of his chosen industry — Listwin was CEO of Openwave Systems and had been the number two executive at Cisco Systems — he took on cancer with the same drive and determination, launching the Canary Foundation.
Listwin says early-detection research like that taking place at UCalgary is key to ensuring victims become survivors. “The work taking place here in Calgary on diagnostic tools that will allow for early detection of high-mortality, treatment-resistant cancers is vital to our goal,” he says. “We are proud and enthused to be supporting the University of Calgary’s Early Cancer Detection Initiative.”
A partnership established by the Arnie Charbonneau Cancer Institute between the Schulich School of Engineering, the Cumming School of Medicine, and the Tom Baker Cancer Centre, the pan-university Early Cancer Detection Initiative’s mission is three-fold. Namely to develop strategies and methods for non-invasive earlier detection of cancer, discover better ways to predict the behaviour of individual cancers, and accelerate the development of new commercially viable cancer detection tests and technologies.
Led by bioengineering professor Kristina Rinker, PhD, the Early Cancer Detection Initiative team, including medical oncologist Dr. Don Morris and surgical oncologist Dr. Oliver Bathe of the Charbonneau Cancer Institute and the Department of Oncology, aims to engage with researchers across campus.
The goal is to advance cancer detection technology development through providing funding opportunities, fostering interdisciplinary collaborations, and building connections to local and international mentors, researchers, and resources. Researchers are currently investigating new ways of detecting those at risk of developing cancer, through blood tests for detecting early disease, body fluid analysis, and technologies to detect metastatic cancer, among other key projects.
Rinker is director of the Centre for Bioengineering Research and Education, and associate professor of Chemical and Petroleum Engineering at the Schulich School of Engineering, associate professor in the Department of Physiology and Pharmacology at the CSM and member of the Charbonneau Cancer Institute. She says the Canary Foundation’s support is a significant boost to the research taking place in Calgary, and it places the university in a position to work and collaborate with the world’s best.
“We are very excited to join the dedicated international team of researchers in the Canary network to detect cancer earlier and open doors to stopping or even reversing cancer progression,” explains Rinker.
The University of Calgary’s multidisciplinary Engineering Solutions for Health: Biomedical Engineering research strategy is focused on developing solutions for pressing health challenges in disease and injury prevention, diagnosis and treatments. Researchers are applying systems engineering principles to continuously improve the health system.
This article by Michael Platt originally appeared on the University of Calgary website (www.ucalgary.ca).